Category: Statistics

Turk J Pediatr. 2025 Jul 6;67(3):327-337. doi: 10.24953/turkjpediatr.2025.5532.

ABSTRACT

BACKGROUND: Pulmonary hemorrhage (PH) leads to acute and catastrophic deterioration in neonates, and there is no curative treatment available. Off-label use of recombinant Factor VIIa (rFVIIa) is a promising treatment to control bleeding. The aim of this study was to investigate the efficacy and safety of rFVIIa in neonatal massive PH.

METHODS: We used rFVIIa for PH in our neonatology unit during October 2022. We compared demographic and prognostic data of neonates with PH, for two years prior to and following this time point. Intravenous rFVIIa (50-90 μg/kg/dose) was administered to patients with life-threatening PH that was unresponsive to conventional therapies including surfactant administration, vitamin K treatment, blood product transfusion, increasing airway pressure, high frequency ventilation, and endotracheal adrenaline. Potential side effects, such as thromboembolism, were monitored for one week.

RESULTS: We present 16 neonates (7 females; 14 preterm) treated with rFVIIa in addition to conventional treatments and compared their clinical outcomes with the rFVIIa-untreated group (n=21). Median (interquartile range [IQR]) birth weight (960 [775-2377] vs 910 [710-1360] g, p=0.20) and gestational age (29 [27-32] vs 27 [27-29] weeks, p=0.25) did not significantly differ between the groups. Median (IQR) postnatal day of PH occurrence was 7.5 (3-15) in the rFVIIa-treated group and 3 (1.5-6) in the rFVIIa-untreated group (p=0.019). Overall, six neonates died of PH complications in the intervention group. All neonates responded to rFVIIa to varying degrees (cessation of bleeding, n=11; reduced bleeding, n=5). A second dose was required in three. No thromboembolism was observed during the treatment period. Death attributable to PH [6 (37%) vs 16 (76%), p=0.042] and overall mortality (7 [43%] vs 18 [86%], p.

PMID:40674767 | DOI:10.24953/turkjpediatr.2025.5532

Turk J Pediatr. 2025 Jul 6;67(3):293-303. doi: 10.24953/turkjpediatr.2025.5744.

ABSTRACT

BACKGROUND: Substance use is rapidly increasing in the pediatric age group worldwide. There is not enough toxicological data on substance use among children and adolescents in Türkiye. This study aims to reveal the forensic toxicological characteristics of cases under the age of eighteen with substance use detected.

METHODS: In our study, forensic toxicological reports of biological samples taken from 587 cases brought to our institution by law enforcement officers due to allegations and/or suspicions of substance abuse between January 1, 2022, and June 30, 2024 were retrospectively examined. The cases were reviewed in terms of variables such as gender, age, age group, substance type (if any), and presence of multiple substance use.

RESULTS: Out of the cases, 89.1% (n=523) of the cases were male and 10.9% (n=64) were female. The majority of cases (93.2%) were observed in the 15-17 age group, accounting for 547 individuals. Of the cases, 29.0% (n = 170) were identified as multiple substance users. Amphetamine-type stimulants (ATS) were present in 68.7% (n = 403) and cannabis was found in 48.2% (n = 283) of cases. It was observed that only cannabis use was significantly higher among males and only ATS use was higher among females (Cramer’s V = 0.202, p < 0.001). The association between gender and substance type was statistically significant; however, the strength of the association was small to moderate.

CONCLUSION: This study assessed substance use profiles in adolescent populations through substance testing. ATS were the most frequently detected substances. The analysis revealed a significant increase in the proportion of female cases over time. While cannabis use was more prevalent among males, ATS use was more common among females. Collecting objective, valid, and definitive data will facilitate the identification of substance use issues and support the development of effective preventive policies.

PMID:40674764 | DOI:10.24953/turkjpediatr.2025.5744

Turk J Pediatr. 2025 Jul 8;67(3):372-384. doi: 10.24953/turkjpediatr.2025.5782.

ABSTRACT

BACKGROUND: Disruptive behaviors (DB) are common problems in young children. The aim of the current study was to highlight the effect of disruptive behaviors on functionality in preschool children and their families and identify factors that may be related to functionality.

MATERIALS AND METHODS: A total of 223 patients were included in the current study from the Turkish Validity and Reliability Study of Preschool Age Psychiatric Assessment (PAPA). The disruptive behavior problems group (n=93) was selected according to PAPA and consisted of patients who had more than 3 conduct problem symptoms, with these symptoms leading to impairment. The control group (n=130) was selected from patients with no disruptive behavior disorder and 3 or fewer conduct problem symptoms . Preschool Age Psychiatric Assessment and Child Behavior Checklist for Ages 1.5-5 (CBCL/1½-5) were used for assessment.

RESULTS: We found that spanking with the hand, verbal dispraise, and selective negative view to child were more frequent in the DB group than in the control group. DB symptoms were found to have a negative impact both on the child’s functioning in several areas and on the parent’s life in specific areas. Additionally, most of the CBCL scores were significantly higher in the DB group. Finally, it was shown that not only disruptive symptoms but factors such as the presence of attention deficit hyperactivity disorder, parental psychopathology, and the age of the child predicted impairment in this functioning.

CONCLUSION: These findings emphasize that parents’ and child’s functionalities can be highly affected by disruptive problems even in an early period such as preschool and that this area should not be ignored in evaluation and interventions.

PMID:40674763 | DOI:10.24953/turkjpediatr.2025.5782

Turk J Pediatr. 2025 Jul 6;67(3):338-348. doi: 10.24953/turkjpediatr.2025.5804.

ABSTRACT

BACKGROUND: Children with cleft palate (CP) are at high risk for otitis media with effusion (OME), which may impair hearing, speech, and development. Although ventilation tube (VT) insertion during palatoplasty is common, its universal use is debated due to uncertain long-term benefits and potential complications. This study aimed to identify preoperative audiological predictors of VT necessity and evaluate VT-related complications.

METHODS: A retrospective review was conducted on 65 non-syndromic CP patients who underwent palatal repair without prior or concurrent VT placement. Preoperative audiological evaluations were performed, and patients were followed postoperatively for VT insertion and complications. Preoperative hearing thresholds, cleft severity (Veau classification), and VT related complications were analyzed statistically.

RESULTS: The likelihood of VT insertion rose significantly in parallel with the severity of preoperative hearing loss, ranging from just 5.9% in patients with normal hearing to 75% in those with moderate conductive hearing loss (CHL) (p < 0.001). Pairwise comparisons showed significant differences between normal hearing and both mild (p = 0.0026) and moderate CHL (p = 0.01). CP severity was not associated with preoperative hearing but correlated with higher VT placement (Veau I: 10%, Veau IV: 69.2%; p = 0.035). Complications included otorrhea (45.2%), early extrusion (35.5%), and tympanic membrane perforation (12.9%), with no significant associations to preoperative hearing level and CP severity.

CONCLUSION: Preoperative hearing level at the time of palate repair is a strong predictor of VT need in CP patients. Mild to moderate CHL significantly increases the risk of persistent OME, supporting early intervention. Normal or slight loss often resolves without treatment, favoring a conservative approach. Higher cleft severity is associated with increased VT placement rates; it does not correlate with preoperative hearing levels or increased VT-related complications. These findings highlight the value of individualized, hearing-based decisions over routine tube placement.

PMID:40674761 | DOI:10.24953/turkjpediatr.2025.5804

Turk J Pediatr. 2025 Jul 6;67(3):304-316. doi: 10.24953/turkjpediatr.2025.5886.

ABSTRACT

BACKGROUND: This study aimed to examine the socio-demographic factors associated with measles vaccination coverage among Indonesian children aged 12-23 months, using data from a nationally representative survey.

METHODS: A cross-sectional analysis was conducted using the 2018 Indonesian Basic Health Survey (Riskesdas), including 19,425 children aged 12-23 months. Multivariate logistic regression was used to identify factors associated with measles vaccination status, and subgroup analyses were performed across three regional clusters.

RESULTS: Of the children surveyed, 73.46% had received measles vaccination, 68.14% had at least one antenatal care visit per trimester, and 53.59% had received at least one postnatal care visit. The most significant predictors of measles vaccination were frequent postnatal care (AOR: 2.36, 95% CI: 1.86-2.99) and higher maternal education (AOR: 2.31, 95% CI: 1.30-4.10). Other associated factors included the age and employment status of the head of the household (as defined by the Riskesdas study), travel time to healthcare facilities, household expenditure, and urban-rural residence.

CONCLUSION: Utilization of postnatal care and higher maternal education were key determinants of measles vaccination coverage. Improving maternal healthcare access and promoting female education may enhance vaccination uptake among Indonesian children.

PMID:40674759 | DOI:10.24953/turkjpediatr.2025.5886

Turk J Pediatr. 2025 Jul 6;67(3):398-409. doi: 10.24953/turkjpediatr.2025.6049.

ABSTRACT

BACKGROUND: Hypospadias, a congenital condition characterized by the urethral opening being on the underside of the penis, has received limited attention in its association with the MTHFR C677T variant. Given the crucial role of folate metabolism in embryonic development, and the involvement of the MTHFR C677T polymorphism in folate metabolism, this study aims to investigate whether this variant contributes to the risk of hypospadias in an Algerian population.

METHODS: This case-control study included 105 patients with hypospadias and 125 controls. Genotyping of the MTHFR gene C677T variant was performed using polymerase chain reaction-restriction fragment length polymorphism.

RESULTS: A statistically significant difference in the genotype distribution of the MTHFR C677T variant between patients with hypospadias and controls was revealed. The significance was observed in the codominant genetic model CT vs. CC (p=0.034, odds ratio [OR]: 1.89, 95% CI: 1.04-3.44) and TT vs. CC (p=0.042, OR: 2.15, 95% CI: 1.02-4.53), as well as in the dominant model CC vs. CT+TT (p=0.010, OR: 1.98, 95% CI: 1.17-3.35). Maternal periconceptional folic acid supplement intake showed a significant association with the anatomical types of hypospadias in relation to the MTHFR C677T genotypes when folic acid was taken (p=0.006). Furthermore, a significant association was observed with the TT genotype in isolated hypospadias cases (p=0.038, OR=3.47, 95% CI: 1.03-11.68), suggesting a potential role of folic acid in modifying hypospadias risk. Multiple logistic regression analysis identified intrauterine growth restriction, gestational hypertension, residency, and the MTHFR C677T variant as independent potential risk factors for hypospadias development (p-values: 0.030, 0.016, 0.040, and 0.045, respectively).

CONCLUSIONS: This study reports, for the first time, an association between the MTHFR gene C677T variant and hypospadias in the Algerian population. The findings suggest a strong association between the MTHFR C677T variant and susceptibility to hypospadias. Identified risk factors such as intrauterine growth restriction, gestational hypertension, rural residency, and the MTHFR C677T variant contribute valuable insights into the multifaceted etiology of hypospadias in this population.

PMID:40674756 | DOI:10.24953/turkjpediatr.2025.6049

FP Essent. 2025 Jul;554:19-24.

ABSTRACT

Personality disorders describe enduring, pervasive, pathologic patterns of behavior and inner experiences that deviate from a patient’s culture. Personality disorders are divided into three clusters depending on core features. Diagnosis of a personality disorder is generally made based on criteria from the Diagnostic and Statistical Manual of Mental Disorders, although other diagnostic modalities exist. The most common disorders in primary care settings include obsessive-compulsive personality, narcissistic personality, and borderline personality disorders. Obsessive-compulsive personality disorder is associated with pathologic perfectionism and intense rigidity. Treatment is primarily psychotherapy, although there is some evidence for using selective serotonin reuptake inhibitors. Narcissistic personality disorder is marked by grandiosity, need for admiration, and a lack of empathy. Psychotherapy is the primary treatment. Borderline personality disorder is associated with instability and intense reactivity, and the primary treatment is typically psychotherapy. Dialectical behavior therapy was developed specifically for borderline personality disorder, although evidence suggests other behavior therapies may be as beneficial.

PMID:40674742

FP Essent. 2025 Jul;554:7-12.

ABSTRACT

Attention-deficit/hyperactivity disorder (ADHD) is characterized by the inability to regulate attention and/or symptoms of hyperactivity that interfere with some level of daily functioning. Although this disorder is well-recognized in children, it is less frequently diagnosed and treated in adults. The pathogenesis of ADHD is not well understood, but norepinephrine and dopamine appear to play roles in the disorder because they modulate the area of the brain involved in attention and behavior regulation. ADHD has a high comorbidity rate, particularly with substance use disorder. Screening for ADHD can be performed in the primary care setting with tools such as the Adult ADHD Self-Report Scale. Diagnosis should be made based on the Diagnostic and Statistical Manual of Mental Disorders criteria, which lists symptoms of inattention and hyperactivity-impulsivity separately. For adults, diagnosis requires patients to have at least five of the symptoms in either category for more than 6 months. Symptoms must have been present before age 12 and must have occurred in at least two independent settings. Treatment is generally a combination of cognitive behavior therapy and stimulant medications, usually amphetamines, although exceptions exist based on comorbid conditions.

PMID:40674740

Obstet Gynecol. 2025 Jul 17. doi: 10.1097/AOG.0000000000006013. Online ahead of print.

ABSTRACT

OBJECTIVE: To compare the efficacy of intramuscular (IM) methotrexate in patients with recurrent compared with primary ectopic pregnancy.

DATA SOURCES: Systematic searches of the MEDLINE, EMBASE, and Scopus databases were conducted in February 2025.

METHODS OF STUDY SELECTION: This meta-analysis was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. All English-language, full-text studies in which adult patients (18 years of age or older) were treated with IM methotrexate and stratified by their history of a previous ectopic pregnancy were included. Patients with at least one prior ectopic pregnancy, regardless of which fallopian tube was affected and how it was managed, were defined as having recurrent ectopic pregnancy. We excluded studies that did not report patients requiring further treatment, those in which medical management through alternative routes (other than IM) or therapies were studied, and those investigating nontubal ectopic pregnancy or heterotopic pregnancies.

TABULATION, INTEGRATION, AND RESULTS: Two investigators independently identified studies using the eligibility criteria. The primary outcome was treatment success, characterized by the complete resolution of ectopic pregnancy without the need for further treatment. The efficacy of single-dose and multidose (comprising both two doses and fixed multidose, ie, two or more doses) IM methotrexate regimens was evaluated. Outcomes were reported as relative risk (RR) and 95% CI. From 6,349 search results, 15 observational studies comprising 3,944 patients (502 recurrent, 3,442 primary ectopic pregnancy) were included. Administration of a single dose of IM methotrexate was significantly less successful in patients with recurrent compared with those with primary ectopic pregnancy (RR 0.79, 95% CI, 0.63-1.00, P=.050). However, there was no statistical difference in success for patients receiving multidose treatment (RR 1.14, 95% CI, 0.71-1.84, P=.590).

CONCLUSION: Current observational data suggest that patients with recurrent ectopic pregnancy should be considered for multidose IM methotrexate to achieve similar rates of success compared with primary ectopic pregnancy.

SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42025642895.

PMID:40674737 | DOI:10.1097/AOG.0000000000006013

JMIR Form Res. 2025 Jul 17;9:e65320. doi: 10.2196/65320.

ABSTRACT

BACKGROUND: Advancements in science and technology can exacerbate health disparities, particularly when there is a lack of diversity in clinical research, which limits the benefits of innovations for underrepresented communities. Programs like the All of Us Research Program (AoURP) are actively working to address this issue by ensuring that underrepresented populations are represented in biomedical research, promoting equitable participation, and advancing health outcomes for all. African American communities have been particularly underrepresented in clinical research, often due to historical instances of research misconduct, such as the Tuskegee Syphilis Study, which have deeply impacted trust and willingness to participate in research studies. With the US population becoming increasingly diverse, it is crucial that clinical research studies reflect this diversity to improve health outcomes. However, limited data and small sample sizes in qualitative studies on the inclusion of underrepresented groups hinder progress in this area.

OBJECTIVE: The goal of this paper is to analyze recruitment conversations between research assistants (RAs) and potential participants in the AoURP to identify key topics that influence enrollment. By examining these interactions, we aim to provide insights that can improve engagement strategies and recruitment practices for underrepresented groups in biomedical research.

METHODS: Our study design was an observational, retrospective approach using machine learning for content analysis. Specifically, we used structural topic modeling to identify and compare latent topics of conversation in recruitment calls by Morehouse School of Medicine RAs between February 2021 and April 2022 by estimating expected topic proportions in the corpus as a function of enrollment and participation in AoURP.

RESULTS: In total, our model estimated 45 topics of which 12 coherent topics were identified. Notable topics, that were more likely to occur in conversations between RAs and participants that enrolled and participated, include closing or following up to schedule an appointment, COVID-19 protocols for in-person visits, explaining precision medicine and the need for representation, and working through objections, including concerns about costs, insurance, care changes, and health fears. Topics among potential participants who did not enroll include technical challenges and describing physical measurement visits (eg, collection of basic physical data, such as height, weight, and blood pressure).

CONCLUSIONS: Using an approach that leverages machine learning to identify topical structure and themes with limited human subjectivity is a promising strategy to identify gaps in, and opportunities to improve, the recruitment of underserved communities into clinical trials.

PMID:40674722 | DOI:10.2196/65320