Ann Allergy Asthma Immunol. 2021 Nov 1:S1081-1206(21)01170-4. doi: 10.1016/j.anai.2021.10.031. Online ahead of print.
ABSTRACT
BACKGROUND: The prevalence of sesame allergy is increasing; strict avoidance is the mainstay of therapy. Lately, sesame oral immunotherapy was presented as an alternative treatment, with a high rate of success. Therefore, data about the natural history and the clinical characteristics of patients with persistent sesame allergy are important for the management of sesame allergic patients.
OBJECTIVE: To describe the natural history of sesame allergic patients and the clinical characteristics of patients with spontaneous resolution of sesame allergy compared to patients with persistent sesame allergy.
METHODS: In our retrospective study, electronic health records of patients with sesame allergy diagnosis were reviewed for demographic and clinical data. Statistical analysis of clinical characteristics of patients with spontaneous resolution compared to persistent sesame allergy was performed.
RESULTS: One hundred and ninety patients with sesame allergy were followed for 3.86±4.43 years. Sixty one (32.1%) of them had spontaneous resolution of sesame allergy. Patients with mild, early (before the age of 10 months) first sesame allergic reaction, with smaller than 7 mm skin prick test and without concomitant tree nuts allergy had better resolution rate (56.1%).
CONCLUSION: Sesame allergy spontaneously resolved in about one third of our patients and in more than half of the patients with mild first reaction (grade 1) at a young age (<10 months), with small skin prick test (<7mm) and no concomitant tree nuts allergy. Larger prospective studies, with longer follow up period are needed to better characterize the sesame allergic patients with persistent allergy, who may need oral immunotherapy.
PMID:34737038 | DOI:10.1016/j.anai.2021.10.031
