J Cataract Refract Surg. 2021 Mar 9. doi: 10.1097/j.jcrs.0000000000000640. Online ahead of print.
ABSTRACT
PURPOSE: To evaluate the changes in refractive outcomes and corneal aberrations in central and paracentral keratoconus after Selective transepithelial topography-guided photorefractive keratectomy combined with Accelerated Corneal Collagen Cross-Linking (STARE-X).
SETTINGS: Centro polispecialistico Mediterraneo, Siena Crosslinking Center and University of Messina (Italy).
DESIGN: Prospective, interventional, multi-centric study.
METHODS: One hundred eyes of 100 patients underwent STARE-X protocol. Patients were subdivided into 2 groups: Group 1 with cone located within the central 3-mm zone (50 eyes); and Group 2 (50 eyes) with cone located outside the central 3-mm zone. Follow-up was two years at least for all eyes. Outcome parameters included uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA). Corneal tomography and corneal wavefront aberrations were assessed and compared before and two years after the treatment.
RESULTS: At 2 years UDVA, CDVA improved, as well as sphere, cylinder, K-max reduced after treatment in both groups (p<.001 respectively). Moreover, a statistically significant reduction was observed of total High-Order Aberrations Root Main Square (HOA RMS), Coma RMS and Spherical Aberration (SA RMS) in both groups (p<.001 respectively). However, CDVA improved more in Group 1 than in Group 2 (p<.02).
CONCLUSION: The STARE-X protocol demonstrated effective results in halting keratoconus progression and improving corneal regularity with a safe and effective profile. STARE-X improved both visual acuity and corneal aberration at 2 years. Longer follow-up studies are warranted to observe further long-term CXL flattening effect on the cone.
PMID:33770171 | DOI:10.1097/j.jcrs.0000000000000640
