Ocul Immunol Inflamm. 2021 Apr 7:1-6. doi: 10.1080/09273948.2021.1900276. Online ahead of print.
ABSTRACT
Purpose: This study aimed to evaluate biosimilar adalimumab’s efficacy and safety in patients with Behçet’s uveitis in Iran.Methods: We performed a study on patients who mostly (79.2%) had a failure on conventional treatment with the mean follow-up time of 19.24 months (95% confidence interval (CI), 16.52-21.96). All the enrolled patients were anti-tumor necrosis factor (anti-TNF) naiive. The primary endpoint was best-corrected visual acuity (BCVA) improvement, and the secondary endpoints were changes in macular thickness, vitreous haze grade, anterior chamber (AC) cell grade, prednisolone dose, and the incidence of adverse reactions.Results: Forty-eight patients were enrolled in the study. After adalimumab use, visual acuity improved significantly (p-value˂.001); vitreous haze grade decreased (p-value˂.001), and AC cell grade improved (p-value = .002). Macular thickness decreased, but its change was not statistically significant (p-value = .1). Moreover, adalimumab showed a corticosteroid-sparing effect (p-value = .03).Conclusion: Biosimilar adalimumab (CinnoRA®) is effective and well-tolerated in Behçet’s uveitis.
PMID:33826486 | DOI:10.1080/09273948.2021.1900276
