Nan Fang Yi Ke Da Xue Xue Bao. 2021 Mar 25;41(3):424-429. doi: 10.12122/j.issn.1673-4254.2021.03.16.
ABSTRACT
OBJECTIVE: To explore the changes of small-world network properties in patients with primary insomnia based on resting-state functional magnetic resonance imaging (rs-fMRI).
OBJECTIVE: The rs-MRI data and neurological scale data of 65 patients and 60 matched healthy controls were collected. The brain network was constructed using GRENTA software. SPSS software and network-based statistical analysis methods were used for statistical analysis.
OBJECTIVE: There was no significant difference between the two groups in terms of age, gender or education level (P > 0.05), but PSQI, HAMA and HAMD scale scores differed significantly between the two groups (P < 0.05). Both of the groups showed attributes of the small-world network. Compared with the control group, the patients with insomnia showed lower Cp, γ, Eloc, λ, connectivity, and σ of the small world network (P < 0.05).
OBJECTIVE: Patients with primary insomnia have lower global and local efficiencies than healthy individuals, and their ability to transmit information on the surface topology is impaired. Our data provide objective imaging evidences for the neuropathological mechanism of patients with primary insomnia.
PMID:33849835 | DOI:10.12122/j.issn.1673-4254.2021.03.16
