Minerva Gastroenterol (Torino). 2021 Apr 15. doi: 10.23736/S2724-5985.21.02826-9. Online ahead of print.
ABSTRACT
BACKGROUND: There have been long debates on the introduction of proton pump inhibitors into acute pancreatitis therapy as standard treatment.
SETTINGS AND DESIGN: The aim of the study was to assess endoscopic lesions of the upper gastrointestinal tract in patients hospitalized for acute pancreatitis.
METHODS AND MATERIAL: We carried out a prospective analysis of patients hospitalized in one surgical centre who had an upper gastrointestinal tract endoscopic examination performed during the first 48 hours of hospitalization.
STATISTICAL ANALYSIS USED: We performed analysis of basic descriptive statistics along with the Shapiro-Wilk test, logistic order regression analysis, one-way analysis of variance, and Student’s t-test for independent trials.
RESULTS: From January 2016 to December 2019, 476 patients were hospitalized because of acute pancreatitis. The upper gastrointestinal tract endoscopic examination was performed in 85 patients (n) in the first 48 hours. From the examined group 45 patients (52.94%) developed mild acute pancreatitis, 28 (32.94%) – moderate pancreatitis and 12 (14.12%) – severe pancreatitis. Lesions in the endoscopic imaging were observed in 80 patients (94.12%).
CONCLUSIONS: A very high percentage of patients hospitalized for acute pancreatitis present lesions in the endoscopic imaging of the upper gastrointestinal tract. The standard treatment of AP is the administration of non-steroidal anti-inflammatory drugs, which themselves can cause gastric and duodenal mucosal defects. All these factors indicate the need for standard use of proton pump inhibitors in patients hospitalized for acute pancreatitis.
PMID:33856142 | DOI:10.23736/S2724-5985.21.02826-9
