J Cosmet Dermatol. 2021 Apr 20. doi: 10.1111/jocd.14163. Online ahead of print.
ABSTRACT
OBJECTIVE: To assess the effectiveness of injection of autologous keratin gel and fibroblast for static forehead rhytides rectification as new soft tissue filler.
MATERIALS AND METHODS: Totally 48 volunteers suffering static forehead rhytides received the injection of autologous keratin and fibroblast and 6 volunteers received botulinum toxin type A (BTX-A) and hyaluronic acid(HA) treatment as parallel control. The follow-up study was carried out 1,3, 6, 12 and 24 months after treatment, photographs and satisfactions questionnaire were collected and assessed. All volunteers were independently assessed by blinded evaluators using global aesthetic improvement scores(GAIS). One-way-Anova was used for statistical analysis, and the significant level was α=0.05).
RESULTS: The static forehead rhytides was improved observably after the treatment. It still showed good result even at month 24 after the injection. There is no severe adverse effects observed in the whole procedure.
CONCLUSION: Autologous fibroblast and keratin combined injection might be an ideal therapy in mini-invasiveplastic injection area, which is safe and effective for static forehead rhytides correction, and has a long-term efficacy.
PMID:33876856 | DOI:10.1111/jocd.14163
