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Nevin Manimala Statistics

Is clinical heterogeneity the foremost prominent threat to the validity of meta-analyses?

Acta Anaesthesiol Scand. 2021 May 14. doi: 10.1111/aas.13852. Online ahead of print.

ABSTRACT

Systematic review methodology with meta-analyses have long been regarded as one of the highest forms of research methodology and a cornerstone in many clinical guidelines. A common criticism of this methodology is the handling of the clinical and/or statistical heterogeneity which arises when pooling heterogenous data from different trials, settings and interventions.

PMID:33988875 | DOI:10.1111/aas.13852

By Nevin Manimala

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