J Biophotonics. 2021 May 27:e202100041. doi: 10.1002/jbio.202100041. Online ahead of print.
ABSTRACT
The histopathological diagnosis of cancer is the current gold standard to differentiate normal from cancerous tissues. We propose a portable platform prototype to characterize the tissue’s thermal and optical properties, and their inter-dependencies to potentially aid the pathologist in making an informed decision. The measurements were performed on samples from 10 samples from 5 subjects, where the cancerous and adjacent normal were extracted from the same patient. It was observed that thermal conductivity (k) and reduced-scattering-coefficient (μ’s ) for both the cancerous and normal tissues reduced with the rise in tissue temperature. Comparing cancerous and adjacent normal tissue, the difference in k and μ’s (at 940 nm) were statistically significant (p = 7.94e-3), while combining k and μ’s achieved the highest statistical significance (6.74e-4). These preliminary results promise and support testing on a large number of samples for rapidly differentiating cancerous from adjacent normal tissues. This article is protected by copyright. All rights reserved.
PMID:34042303 | DOI:10.1002/jbio.202100041
