Am J Hypertens. 2021 Jun 9:hpab084. doi: 10.1093/ajh/hpab084. Online ahead of print.
ABSTRACT
BACKGROUND: Although previous studies have reported the gut microbiome is closely related to hypertension development, whether the change in blood microbiome is associated with the risk of hypertension remains unclear.
METHODS: One hundred and fifty incident hypertension cases and 150 age (± 2 years) and gender (1:1) matched non-hypertension controls included in this nested case-control study were recruited from a prospective cohort study of “135”. The composition of the blood microbiome was characterized using bacterial 16S ribosomal RNA gene sequencing. The relative abundance of detected bacteria was converted to a negative logarithm of 10 for the statistical analysis.
RESULTS: Totally, 10,689,961 high-quality sequences were acquired. The Chao1 index of the blood microbiome in non-hypertension controls was significantly higher than that in hypertensive group (2302.08±752.78 vs 1598.21±500.88, P < 0.001). Compared with the non-hypertension controls, the relative abundance of Proteobacteria phylum was significantly increased (P<0.001), while the relative abundance of phyla Firmicutes and Bacteroidetes were significantly reduced in the hypertensive cases (P<0.001 and P=0.039, respectively). At genus level, the risk of hypertension was directly associated with the relative abundance ofAcinetobacter(OR: 1.43, 95% CI: 1.01-2.03),Sphingomonas(OR: 1.84, 95% CI: 1.32-2.56), andStaphylococcus(OR: 0.51, 95% CI: 0.36-0.73), respectively.In addition, the relative abundance of Pseudomonas was minor positively correlated to the TC level. However, the relative Staphylococcus level was minor positively correlated to HDL-c level.
CONCLUSIONS: The composition of the blood microbiome is significantly associated with the development of hypertension.
PMID:34105723 | DOI:10.1093/ajh/hpab084
