Clin Oral Implants Res. 2021 Jun 26. doi: 10.1111/clr.13803. Online ahead of print.
ABSTRACT
OBJECTIVES: Purpose of this experimental in-vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the de novo bone formation and osseointegration.
MATERIAL AND METHODS: The study was designed as an animal pre-clinical trial with intra-animal control and two healing periods, 2 and 8 weeks, to compare implants with an identical macro-design but with two different surfaces. Eight female Beagle dogs participated in the study. Control implants had a moderately rough surface combining sandblasting and acid etching; test implants had an additional monophosphonate layer covalently bonded to titanium. Histologic and radiographic (microCT) outcome variables were evaluated.
RESULTS: The first bone to implant contact (fBIC) was located more coronally for the test implants at the first (0.065 mm (95%CI = -0.82, 0.60)) and second healing milestones (0.17 mm (95%CI = -0.9, 0.55)). Most coronal BIC of the test implants displayed a higher percentage of osseointegration, + 6.33% and + 13.38% after 2 and 8 weeks, respectively; however the differences were not statistically significant. The microCT examination did not show any BIC difference.
CONCLUSIONS: The monophosphonate layer coating demonstrated clinical, histological and radiographic results similar to the control surface.
PMID:34174121 | DOI:10.1111/clr.13803
