J Med Virol. 2021 Jun 28. doi: 10.1002/jmv.27161. Online ahead of print.
ABSTRACT
OBJECTIVE: The role of human papillomavirus (HPV) in development of oral lesions is controversial. There is no comprehensive study about HPV prevalence in Iran. This systematic review and meta-analysis was aimed to find HPV prevalence of oral lesions and normal oral mucosa in Iran.
METHODS: International (PubMed, Web of Science and Scopus) and national (Iranmedex, Irandoc and SID) database were searched systematically until October 2020. Studies which examined prevalence of HPV in oral lesions by polymerase chain reaction method were included. The heterogeneity of articles was assessed with the Cochran Test and I-Square statistics. The prevalence rate of HPV was calculated using random effect model.
RESULTS: Of 3729 initial searched articles, 29 articles were eligible to include. Overall prevalence of HPV in oral lesions was 21%. The prevalence was highest in Rasht (50%) city. lip lesions had the highest HPV prevalence (40%). According to classification of lesions, the highest prevalence was in precancerous lesions (29%) and the lowest in normal mucosa (8%). Well-differentiated tumor showed higher prevalence than poorly-differentiated ones. The highest prevalence of HPV was in hairy leukoplakia (70%) and the lowest was in pyogenic granuloma (6%). Also, the prevalence was 31% in oral squamous cell carcinoma.
CONCLUSION: There are differences between HPV prevalence according to geographical area, intraoral location, type of lesion and grading. Since HPV prevalence was approximately high, further attention to vaccination and treatment for HPV in Iranian, as a potential risk factor for oral precancerous and cancerous lesions is recommended. This article is protected by copyright. All rights reserved.
PMID:34180541 | DOI:10.1002/jmv.27161
