Ann Hepatobiliary Pancreat Surg. 2021 Jun 30;25(Suppl 1):S175. doi: 10.14701/ahbps.BP-PP-4-7.
ABSTRACT
INTRODUCTION: It is known that gallbladder cancer (GBC) in the neck or cystic duct (NC-GBC) has a better prognosis than GBC in the fundus or body (FB-GBC), but systematic studies on this are insufficient. We performed this study to investigate the impact of longitudinal tumor location on postoperative outcomes in patients undergoing resection for GBC.
METHODS: A retrospective study was conducted for patients who underwent a radical resection for GBC from February 2008 to November 2017 at the Dankook University Hospital. A total of 98 patients underwent surgery for GBC, of which 77 patients who underwent curative intent surgery were included in the study. They were classified into FB-GBC and NC-GBC groups according to longitudinal tumor location, and the postoperative outcomes were compared and analyzed.
RESULTS: There were no significant differences in the clinicopathological characteristics, TNM stage, postoperative complications, and in-hospital mortality between two groups. However, NC-GBC significantly showed more sclerotic gross type, poorer differentiation, and more lymphatic and perineural microinvasion. The radical resection rate was statistically higher in FB-GBC group (93.1% vs. 73.7%; p = 0.036) and adjuvant 5-FU based CCRT was more carried out in NC-GBC group (19.0% vs. 57.9%; p < 0.001). The recurrence rates after surgery was statistically higher in NC-GBC group (25.9% vs. 52.6%, p = 0.047), but there were no differences in disease-free survival (DFS) and overall survival (OS).
CONCLUSIONS: Although NC-GBC showed more aggressive microscopic pathological findings and higher recurrence rate than FB-GBC, there were no differences in DFS and OS according to longitudinal tumor location of GBC.
PMID:34227535 | DOI:10.14701/ahbps.BP-PP-4-7
