Int J Clin Pract. 2021 Jul 29:e14665. doi: 10.1111/ijcp.14665. Online ahead of print.
ABSTRACT
PURPOSE: Methylphenidate hydrochloride is used as a first-line treatment for Attention Deficit Hyperactivity Disorder (ADHD). However, there is concern that this treatment may be associated with increased risk of refractive disorder. The aim of this study was to investigate the effect of methylphenidate therapy on myopic shifts in refraction in children diagnosed with ADHD.
METHODS: This study, children with ADHD and meeting inclusion criteria were examined before the initiation of methylphenidate treatment and 3,6 and 12 months after the initiation of treatment. Twenty age-gender matched participants who applied to the outpatient ophthalmology clinic with various complaints were included in the study as a control group. Cycloplegic refraction examination and detailed eye measurements were performed at each visit.
RESULT: Nineteen patients were included in this study and the group consisted of 11 (%57.9) females and 8 (%42.1) males. The mean age of patients was 11.3 ± 2. (range 8-18) years. During 12 months of use of mph, the spherical equivalent changed from -0.36 ± 1.08 to -0.39 ± 1.05, and this difference was not statistically significant. (p = 0.187) Axial length from 22.92 ± 0.66 There was a change to 22.93 ± 0.62, and this difference was not statistically significant. (p = 0.076) In the control group, the spherical equivalent changed from -0.43 ± 0.62 to -0.56 ± 0.84, and this difference was statistically significant. (p = 0.012) There was a change in axial length from 22.97 ± 0.78 to 22.99 ± 0.62, and this difference was statistically significant. (p = 0.015) CONCLUSION: No significant changes spherical equivalent and axial length were detected during 12-month mph use, but the increase spherical equivalent and axial length in the control group in the similar age group may indicate that mph may reduce myopic shifts in refraction progression through dopamine, similar to invivo studies.
PMID:34324770 | DOI:10.1111/ijcp.14665
