Dig Endosc. 2021 Aug 9. doi: 10.1111/den.14103. Online ahead of print.
ABSTRACT
BACKGROUND AND AIM: Underwater endoscopic mucosal resection (UEMR) have been reported as effective endoscopic treatment for superficial duodenal tumors (SDETs). However, it has been reported that a notable problem of UEMR for SDETs is that en bloc resection rate is relatively low. Therefore, we proposed a novel technique to improve en bloc resection rate: UEMR combining partial submucosal injection (PI-UEMR). The aim of this study is to evaluate efficacy and safety of PI-UEMR for SDETs by comparing to UEMR.
METHODS: This is a retrospective observational study in a single-center. The patients who underwent UEMR or PI-UEMR from June 2010 to August 2020 ware included in this study. Eligible patients were selected from included patients in a 1 :1 ratio using propensity score matching. The clinical outcomes of endoscopic resection [procedure time, En bloc resection rate, complication rate (immediate perforation, delayed bleeding, delayed perforation)], and histopathological diagnosis (Adenoma/Cancer) were compared between each group.
RESULTS: Two-hundred twenty-eight patients were included in this study. Of included patients, 47 patients were selected in each group by propensity score matching. There were no statistical differences in procedure time (11±1.2min vs 9±1.2min, p=0.30), complication rate [immediate perforation (0% vs 2%, p=0.12), delayed bleeding(0% vs 2%, p=0.12),and no delayed perforation] and histopathological diagnosis (Adenoma; 100% vs 96%, p=0.14) in each group. However, en bloc resection rate of PI-UEMR was significantly higher than UEMR (96% vs 83%, p <0.05).
CONCLUSION: PI-UEMR might be superior procedure for en bloc resection in SDETs compare to UEMR.
PMID:34370891 | DOI:10.1111/den.14103
