Eur J Dent. 2021 Aug 24. doi: 10.1055/s-0041-1729677. Online ahead of print.
ABSTRACT
OBJECTIVE: The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats.
MATERIALS AND METHODS: Twenty-four Wistar rats were randomized into four groups (n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima, in a concentration of 25 and 40 mg·mL1, respectively; the MO group was treated with Monsel’s solution and the control group SC with a 0.9% sodium chloride solution.
STATISTICAL ANALYSIS: Data were submitted to the Kurskal-Wallis’ test, followed by Dunn’s post hoc (p < 0.05).
RESULTS: There was a significant reduction in the bleeding time of the group from the JM25 extract (p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 (p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group (p = 0.001). Monsel’s solution showed significant bleeding, six times greater than the control group SC.
CONCLUSION: The J. mollissima extract, in the concentration of 25 mg·mL1, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.
PMID:34428842 | DOI:10.1055/s-0041-1729677
