J Med Virol. 2021 Aug 30. doi: 10.1002/jmv.27311. Online ahead of print.
ABSTRACT
OBJECTIVE: to analyze the distribution of HPV genotype, cytology and the clinical characteristics of VaIN.
METHODS: All patients with histological-proven VaIN at West China Second University Hospital, between January 1, 2014, and October 1, 2020 were retrospectively identified. Demographics, medical history, HPV genotype, viral load and cytology results were retrieved. Standard statistical analyses were conducted.
RESULTS: Of 3229 patients included, 42.3% were diagnosed with VaIN 1, 30.3% with VaIN 2 and 27.4% with VaIN 3. Patients with VaIN 3 were the oldest (p<0.001). The leading HPV genotypes were HPV 16, 52, 58, 53, 56 and 81. The positive rate HPV 16 was positively correlated with the grade of VaIN and infected most of VaIN 3 patients (76.0%). The sensitivities of cytology for VaIN only, concomitant VaIN and VaIN after hysterectomy were 75.6%, 78.8% and 82.9%, respectively (p=0.013), and the sensitivities of HPV were 91.1%, 93.5% and 91.7%, respectively (p=0.205). Cotesting improved the sensitivities, up to 96.9%, 97.1% and 98.1%, respectively.
CONCLUSIONS: VaIN can occur alone or be concomitant with cervical or vulvar intraepithelial neoplasia. Most of VaIN 2/3 are infected with HPV 16. The sensitivity of cytology and HPV testing is non-inferior to that of CIN 2+. Therefore, these testing might be helpful in the early detection of VaIN. This article is protected by copyright. All rights reserved.
PMID:34460120 | DOI:10.1002/jmv.27311
