Clin Exp Pharmacol Physiol. 2021 Aug 29. doi: 10.1111/1440-1681.13586. Online ahead of print.
ABSTRACT
The postmenopausal stage in women’s life is associated with the enhancement of inflammation that may be reduced using soy isoflavones or soy protein. The present study aimed to summarize the effect of soy isoflavones and soy protein on circulating interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in postmenopausal women. The English-language articles were identified from the databases such as Cochrane Library, clinicaltrials.gov, Web of Science, PubMed, and Scopus until December 2020. The mean change from baseline and its standard deviation (SD) for intervention and comparison groups were used to calculate the effect size. The statistical heterogeneity of the intervention effects was computing by Cochran’s Q test and I-squared statistic. Nine and seven studies were selected for systematic review and meta-analysis respectively. The results of our meta-analysis indicated a non-significant effect on the serum concentrations of IL-6 and TNF-α (weighted mean differences (WMD)=0.07 pg/mL; 95% confidence interval (CI): -0.03, 0.17 pg/mL; P=0.190; WMD=0.05 pg/mL; 95% CI: -0.01, 0.12 pg/mL; P=0.092; respectively). In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose ≤87 mg/d, cross-over design, weak quality, and studies on participants who had health risk factors or diseases. The serum concentration of TNF-α increased in studies with cross-over design, intervention duration≤56 days, and body mass index (BMI)>27, and in studies which were conducted on at-risk or sick participants. In conclusion, our meta-analysis did not confirm any downward effect on serum concentration of IL-6 and TNF-α among postmenopausal women.
PMID:34455600 | DOI:10.1111/1440-1681.13586
