Int J Clin Pract. 2021 Sep 15:e14873. doi: 10.1111/ijcp.14873. Online ahead of print.
ABSTRACT
AIM: To assess functions of the lower urinary tract (LUT) in patients with myasthenia gravis (MG).
MATERIALS AND METHODS: 36 patients (18 males and 18 females) with MG and 29 healthy controls were enrolled. Participants completed a 3-day voiding diary and responded to questionnaires “Overactive Bladder Symptom Score” (OABSS) and “International Consultation on Incontinence-Short Form” (ICIQ-SF). All patients underwent uroflowmetry and ultrasonography (US). The data were compared based on the onset of disease and serological status.
RESULTS: The most common urinary symptoms were nocturia (80.5%), incontinence (61%), and urgency (47%). OABSS was higher in patients than controls (p= 0.008). Duration of urinary symptoms was longer and nocturia was more common in late-onset MG (LOMG) than in early-onset MG (EOMG) (p= 0.029, p= 0.023). The duration of disease and urinary symptoms statistically increased in ACh-Ab (-) group compared to ACh-Ab (+) group (p= 0.003, p= 0.027). Nighttime urination frequency significantly increased while daytime voided volume (VV) decreased in LOMG compared to EOMG (p= 0.003 and p= 0.01). Residual volume on the US was significantly higher in LOMG than that in EOMG (p= 0.004). The duration of disease was positively correlated with tQmax and daytime urination frequency (p= 0.013, r= 0.48; p= 0.016, r= 0.398). A negative association was found between duration of disease and daytime VV (p= 0.04, r= -0.344).
CONCLUSION: LUT dysfunction may manifest disease in MG, particularly in late-onset forms. The lack of ACh-Ab seemed to prolong the duration of disease and urinary disturbances.
PMID:34525243 | DOI:10.1111/ijcp.14873
