Clin Oral Implants Res. 2021 Sep 22. doi: 10.1111/clr.13841. Online ahead of print.
ABSTRACT
OBJECTIVES: The aim was to evaluate the role of resorbable membranes applied over customized titanium meshes related to soft tissue healing and bone regeneration after vertical/horizontal bone augmentation.
MATERIALS AND METHODS: Thirty patients with partial edentulism of the maxilla/mandible, with vertical/horizontal reabsorption of the alveolar bone, and needing implant-supported restorations, were randomly divided into two groups: Group A was treated using only custom-made meshes (Mesh-); Group B using custom-made meshes with cross-linked collagen membranes (Mesh+). Data collection included: surgical and healing complications, “pseudo-periosteum” thickness, bone density, planned bone volume (PBV), regenerated bone volume (RBV), regeneration rate (RR), vertical bone gain (VBG), and implant survival in regenerated areas. Statistical analysis was performed between the 2 study groups using a significance level of α=0.05.
RESULTS: Regarding the healing complications, the non-inferiority analysis proved to be inconclusive despite the better results of group Mesh+ (13%) compared to group Mesh- (33%); Estimated value -1.13 CI-95% from -0.44 to 0.17. Superiority approach confirmed the absence of significant differences (p=0.39). RBV were 803.27mm3 and 843.13mm3 , respectively; and higher RR was observed in group Mesh+ (82.3%) compared to Mesh- (74.3%), although this value didn’t reach a statistical significance (p=0.44). All 30 patients completed the study, receiving 71 implants; 68 out of them were clinically stable and in function.
CONCLUSION: the results showed that customized meshes alone don’t appear to be inferior to customized meshes covered by cross-linked collagen membranes in terms of healing complication rates and regeneration rates, although superior results were observed in group Mesh+ compared to group Mesh- for all variables.
PMID:34551168 | DOI:10.1111/clr.13841
