Med Phys. 2021 Sep 29. doi: 10.1002/mp.15255. Online ahead of print.
ABSTRACT
PURPOSE: Radiomics, the objective study of non-visual features in clinical imaging, has been useful in informing decisions in clinical oncology. However, radiomics currently lacks the ability to characterize the overall topological structure of the data. This niche can be filled by persistent homology, a form of topological data analysis that analyzes high-level structure. We hypothesized that persistent homology features quantified using cubical complexes could be extracted from lung tumor scans and related to survival.
METHODS: We obtained segmented computed tomography (CT) lung scans (n = 565) from the NSCLC-Radiomics and NSCLC-Radiogenomics datasets in The Cancer Imaging Archive. These scans are three dimensional images whose pixel intensity corresponds to a number of Hounsfield units (HU). Cubical complexes are a topological image analysis method that effectively analyze the number of topological features in an image as the image is thresholded at different intensities. We calculated a novel output called a feature curve by plotting the number of 0 dimensional topological features counted from the cubical complex filtration against each Hounsfield value. This curve’s first moment of distribution was utilized as a summary statistic to show association with survival in a Cox proportional hazards model. We hypothesized that persistent homology features quantified using cubical complexes could be extracted from lung tumor scans and related to survival Results: After controlling for tumor image size, age, and stage, the first moment of the 0D topological feature curve was associated with poorer survival (HR = 1.118; 95% CI = 1.026-1.218; p = 0.01). The patients in our study with the lowest first moment scores had significantly better survival (1238 days; 95% CI = 936-1599) compared to the patients with the highest first moment scores (429 days; 95% CI = 326-601; p = .0015).
CONCLUSIONS: We have shown that persistent homology can generate useful clinical correlates from tumor CT scans. Our 0-dimensional topological feature curve statistic predicts survival in lung cancer patients. This novel statistic may be used in tandem with standard radiomics variables to better inform clinical oncology decisions.
PMID:34587294 | DOI:10.1002/mp.15255
