Int J Gynaecol Obstet. 2021 Nov 11. doi: 10.1002/ijgo.14015. Online ahead of print.
ABSTRACT
BACKGROUND: Pregnant patients are potentially vulnerable to COVID-19.
OBJECTIVES: To clarify the clinical features of COVID-19 and analyze maternal/fetal morbidity and mortality and the obstetric and neonatal outcomes of pregnant patients.
SEARCH STRATEGY: Embase, PubMed, Web of Science, CINAHAL, LILACS, Google Scholar, and Scopus.
SELECTION CRITERIA: Articles published from December 2019 to February 2021.
DATA COLLECTION AND ANALYSIS: The reviewers extracted relevant data from the full-text. Data synthesis was performed using the R-4.1.0 Project for Statistical Computing for Windows. The meta-analysis of the included studies was carried out using the random-effects model (DerSimonian and Laird). Heterogeneity was measured using I2 analysis.
RESULTS: A total of 70 studies included 10 047 pregnant women with COVID-19, of whom 71.6% were in their third trimester. The most common symptoms were fever, cough, chest pain, dyspnea, and fatigue. Most newborns were delivered preterm (24%, 95% confidence interval [CI] 0.17-0.34, I2 =93%) and via cesarean delivery (42%, 95% CI 0.38-0.47, I2 =92%). There were 108 maternal mortalities (2%, 95% CI 0.01-0.03, I2 =54%) and 50 abortions (5%, 95% CI 0.03-0.09, I2 =73%). The neonatal outcomes included fetal distress (11%, 95% CI 0.06-0.19, I2 =91%), birth weight (15%, 95% CI 0.10-0.21, I2 =76%), APGAR <7 (19%, 95% CI 0.12-0.28, I2 =43%), admission to the neonatal intensive care unit (28%, 95% CI 0.17-0.43, I2 =90%), and fetal mortality (2%, 95% CI 0.01-0.03, I2 =46%).
CONCLUSION: There was no evidence of severe acute respiratory syndrome coronavirus-2 in the placenta, breast milk, umbilical cord, and amniotic fluid.
PMID:34762735 | DOI:10.1002/ijgo.14015
