J Periodontol. 2021 Nov 13. doi: 10.1002/JPER.21-0428. Online ahead of print.
ABSTRACT
BACKGROUND: Three- dimensional (3D) technology has been suggested to overcome these limitations in guided bone regeneration (GBR) procedures because 3D-printed scaffolds can be easily molded to patient-specific bone defect site. This study aimed to investigate the effect of 3-D printed polylactic acid (PLA) scaffolds with or without hyaluronic acid (HA) in a rabbit calvaria model.
METHODS: A calvaria defect with a diameter of 15 mm was created in 30 New Zealand white rabbits. The rabbits were randomly allocated into 3 groups including no graft group (control, n = 10) , 3D printed PLA graft group (3D-PLA, n = 10) , and 3D printed PLA with hyaluronic acid graft group (3D-PLA/HA, n = 10) . Five animals in each group were sacrificed at 4 and 12 weeks after surgery. Microcomputed tomography and histologic and histomorphometric analyses were performed.
RESULTS: Over the whole examination period, no significant adverse reactions were observed. There were no statistically significant differences in bone volume (BV) /tissue volume (TV) among the three groups at 4 weeks. However, the highest BV/TV was observed in the 3D-PLA/HA group at 12 weeks. The new bone area for control, 3D-PLA, and 3D-PLA/HA showed no statistical differences at 4 weeks. However, the value was significantly higher in the 3D-PLA and 3D-PLA/HA groups compared to the control group at 12 weeks.
CONCLUSION: The 3D printed PLA scaffolds was biocompatible and integrated well with bone defect margin. They were also provided the proper space for new bone formation. Therefore, 3D printed PLA/HA might be a potential tool to enhance bone augmentation. This article is protected by copyright. All rights reserved.
PMID:34773704 | DOI:10.1002/JPER.21-0428
