Chemphyschem. 2021 Dec 1. doi: 10.1002/cphc.202100765. Online ahead of print.
ABSTRACT
We propose here a theoretical model for the influence of confinement on biomolecular binding at the single-molecule scale at equilibrium, based on the change of the number of microstates (localization and orientation) upon reaction. Three cases studies are discussed: DNA sequences shorter and longer than the single strain DNA Kuhn length and spherical proteins, confined into a spherical container (liposome, droplet…). The results show that this influence is highly dependent on the molecular structure and significant for large molecules (relative to container size).
PMID:34856050 | DOI:10.1002/cphc.202100765
