Int J Gynaecol Obstet. 2022 Jan 7. doi: 10.1002/ijgo.14087. Online ahead of print.
ABSTRACT
BACKGROUND: During pregnancy, urinary infections are an important cause of maternofetal morbimortality and may lead to several complications.
OBJECTIVES: Verify whether the use of antibiotic therapy in a single dose when compared to multiple doses in lower tract urinary infections during pregnancy is effective to obtain microbiological cure.
SEARCH STRATEGY: Online databases were searched. Keywords used were “single-drug dose”, “antibiotic”, “fosfomycin”, “amoxicillin”, “trimethoprim”, “pregnancy” and “urinary tract infection”.
SELECTION CRITERIA: Studies were included if: were randomized controlled trials, population was pregnant woman, microbiological cure was attained and one of the treatment groups received single-dose antibiotic therapy.
DATA COLLECTION AND ANALYSIS: Preselected studies have been independently read by pairs, and data were extracted according to a predetermined sheet. The Cochrane tool was used for the risk of bias.
MAIN RESULTS: 1063 women from 9 studies were included. The primary outcome was the microbiological cure attested by urine culture. When compared to the multiple-day use of antibiotics, the single-dose treatment has shown statistically similar results in reaching culture cure (OR 1.02, 95% IC 0.73-1.44).
CONCLUSION: The current study has shown that the use of single dose treatment for lower tract urinary infections during pregnancy can be recommended, specially using fosfomycin.
PMID:34995367 | DOI:10.1002/ijgo.14087
