Int J Gynaecol Obstet. 2022 Jan 19. doi: 10.1002/ijgo.14102. Online ahead of print.
ABSTRACT
OBJECTIVE: To describe the epidemiology of early gestational diabetes mellitus (GDM) based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) defined fasting glycemia MATERIALS AND METHODS: A prospective multicenter study testing fasting venous plasma glucose (FPG) in women aged 18 – 45 years between 6 – 23 6/7 weeks gestation in secondary health facilities in Ondo State, Nigeria. Early GDM was defined using the IADPSG threshold for fasting hyperglycemia, and its severity was examined. Potential risk factors for early GDM were assessed using logistic regression analysis.
RESULTS: Of the 8915 women who underwent FPG testing, the prevalence of early GDM was 12.5% (11.9 – 13.3). Multivariable analysis identified a dose-response association between body mass index (BMI) (kg/m2 ) and early GDM, with a BMI ≥35kg/m2 (aOR 1.92, 95% CI 1.03-3.55) associated with early GDM. Primiparity (aOR 1.49, 95%CI 1.25-1.76), multiparity (aOR 1.73, 95%CI 1.47-2.04) and a first-degree family history of diabetes (aOR 1.60, 95%CI 1.27-2.02) were associated with significantly higher odds of early GDM.
CONCLUSION: This study established the prevalence, severity and risk factors for early GDM in a specific country that potentially represents a global region with no previous relevant data.
PMID:35044685 | DOI:10.1002/ijgo.14102
