J Clin Periodontol. 2022 Feb 7. doi: 10.1111/jcpe.13600. Online ahead of print.
ABSTRACT
BACKGROUND: Acute infection/inflammation increases the risk of acute vascular events. Invasive dental treatments (IDT) trigger short-term acute inflammation.
PURPOSE: To critically appraise the evidence linking IDT and acute vascular events.
DATA SOURCES: Six bibliographical databases were searched up to 31st August 2021. A systematic review following PRISMA guidelines was performed.
STUDY SELECTION: Intervention and observational studies reporting any acute vascular events following IDT.
DATA EXTRACTION: Two reviewers independently extracted data and rated the quality of studies. Data was pooled using fixed effect, inverse variance weights analysis.
RISK OF BIAS: Newcastle-Ottawa Quality Assessment Scale for observational studies and the Cochrane Handbook -Rob 2.0 for randomised controlled trials.
DATA SYNTHESIS: Three out of 16 clinical studies, a total of 533,175 participants, 124,344 myocardial infarctions and of 327,804 ischemic strokes were reported. Meta-analysis confirmed that IDT did not increase incidence ratios (IR) for combined vascular events either at 1-4 weeks (IR of 1.02, 95% CIs: 0.92, 1.13) and at 5-8 weeks (IR of 1.04, 95% CIs-0.97;1.10) after treatment.
LIMITATIONS: High level of heterogeneity (study designs and timepoint assessments).
CONCLUSIONS: Patients who received IDT exhibited no substantial increase in vascular risk over 8 weeks post treatment.
PMID:35132650 | DOI:10.1111/jcpe.13600
