J Clin Periodontol. 2022 Feb 10. doi: 10.1111/jcpe.13603. Online ahead of print.
ABSTRACT
AIM: This study evaluated the intervention effect of omega-3 fatty acids on changes in periodontal parameters.
MATERIALS AND METHODS: This meta-analysis included English-language studies published between 2010 and 2020, which were extracted from the Cochrane Library, EMBASE, and PubMed databases. The effects of omega-3 fatty acid intervention were investigated using the amount of omega-3 intake, periodontal pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP). The random-effects model was generated for data analysis. To obtain robustness of the model, sensitivity analysis was implemented. Subgroup analyses were performed based on the intervention period for each parameter.
RESULTS: All 13 studies included in the meta-analysis were interventional randomized controlled trials. Two studies implemented omega-3 fatty acid-rich diets, while eleven studies used supplements. Risk of bias was low and publication bias was not shown. Meta-analysis showed a statistically significant PPD reduction (standardized mean difference; SMD = -0.81 mm, absolute mean difference; MD = -0.44 mm), CAL gain (SMD = -0.77 mm, MD = -0.51 mm), and BOP reduction (SMD = -0.65%, MD = -9.45%) for the omega-3 fatty acids intervention overall.
CONCLUSION: This study suggests that supplemental or dietary intake of omega-3 fatty acids for the treatment of periodontitis may positively impact on periodontitis.
PMID:35141945 | DOI:10.1111/jcpe.13603
