J Cosmet Dermatol. 2022 Feb 16. doi: 10.1111/jocd.14854. Online ahead of print.
ABSTRACT
BACKGROUND: Pemphigus is a series of autoimmune skin disorders caused by IgG. Regulatory T cells (Tregs) are a subset of CD4+ T cells that mostly block pathogenic immune responses mediated by self-reactive cells, therefore a lack of Tregs or a malfunction in their activity could lead to a loss of tolerance and the development of autoimmunity. .
AIMS: to evaluate the expression of lesional and perilesional Treg markers (CD4+ CD25+ bright FOXP3+) in pemphigus patients.
PATIENTS AND METHODS: Twenty three pemphigus patients and 20 healthy controls were included in this study. The expression of CD4, CD25 and Foxp3 were evaluated by immunohistochemistry.
RESULTS: There was statistically significant increase in CD4+ T lymphocytes in lesional skin of pemphigus compared to perilesional skin and control group (P-value: 0.001). There was statistically significant decrease in CD25+ and Foxp3+ cells in lesional skin compared to perilesional and control group (P-value: <0.001, 0.025 respectively ).
CONCLUSION: The reduction of lesional skin Tregs may play an important role in the pemphigus pathogenesis.
PMID:35174611 | DOI:10.1111/jocd.14854
