Angew Chem Int Ed Engl. 2022 Feb 22. doi: 10.1002/anie.202201700. Online ahead of print.
ABSTRACT
A strategy for the generation of heterotrimetallic double cavity (DC) cages [PdnPtmL4]6+ (DC1: n = 1, m = 2; and DC2: n = 2, m = 1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and Pd(II) ions. 1H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2, were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of the 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities was found to interact with two different guests, 5-FU and cisplatin, selectively.
PMID:35194905 | DOI:10.1002/anie.202201700
