J Hum Nutr Diet. 2022 Mar 3. doi: 10.1111/jhn.13000. Online ahead of print.
ABSTRACT
BACKGROUND: Although effective, the impact of bariatric surgery on weight loss is variable, and little is known about the influence of single nucleotide polymorphisms (SNPs). This study investigated the association of eleven SNPs related to obesity with weight loss one year after Roux-Y gastric bypass (RYGB) surgery in female patients.
METHODS: This prospective study included 351 women with obesity. The genotypes for eleven SNPs (GHRL – rs26802; GHSR – rs572169; LEP – rs7799039; LEPR – rs1137101; 5HT2C – rs3813929; UCP2 – rs659366; UCP3 – rs1800849; SH2B1 – rs7498665; TAS1R2 – rs35874116; TAS1R2 – rs9701796; FTO – rs9939609) were determined using real-time polymerase chain reaction (PCR) and TaqMan assays. Anthropometric measurements were performed before and one year after RYGB surgery. To evaluate the factors that influenced the proportion of weight loss 1 year after surgery, beta regression analysis was used. The models were estimated using the SAS software GLIMMIX procedure. The level of significance adopted for the statistical tests was 5%.
RESULTS: The average percentage of total body weight loss in one year was 64.4 ± 5.8% and the median was 65.0%. In assessing the proportion of weight loss in one year after surgery, using univariate analysis (beta regression), no single nucleotide polymorphisms (SNPs) influenced weight loss. And in the multiple analysis, with stepwise process of variable selection, no variable was significant to compose the multiple model.
CONCLUSION: The 11 SNPs investigated did not influence weight loss one year after RYGB surgery in female patients. This result indicates that individual behaviors and other factors might better contribute to the magnitude of loss weight loss in a short period after bariatric surgery. This article is protected by copyright. All rights reserved.
PMID:35239993 | DOI:10.1111/jhn.13000
