Cytopathology. 2022 Apr 1. doi: 10.1111/cyt.13123. Online ahead of print.
ABSTRACT
OBJECTIVE: The effect of rapid on-site evaluation (ROSE) combined with computed tomography-guided transthoracic core needle biopsy (CT-guided TCNB) is rarely investigated. This study aimed to evaluate the diagnostic efficiency and safety of ROSE combined with CT-guided TCNB for suspected lung cancer patients.
MATERIALS AND METHODS: Clinical data from 285 patients who received CT-guided TCNB for suspected lung cancer in Huashan Hospital from 2015 to 2018 were retrospectively analyzed. 163 of these patients underwent CT-guided TCNB combined with ROSE (ROSE group), while the remaining 122 patients underwent without ROSE (non-ROSE group). The smears obtained from TCNB were quickly processed with Diff-Quick staining and analyzed by one skilled cytologist on-site. The consistency of ROSE with the final clinicopathological diagnosis and the diagnostic efficiency and safety of ROSE combined with CT-guided TCNB in suspected lung cancer patients were evaluated.
RESULTS: ROSE was highly concordant with pathological diagnosis (κ = 0.791; p < 0.001), with the accuracy of 95.7%. The diagnostic accuracy was significantly higher in ROSE group compared with that in non-ROSE group (96.3% vs. 86.1%; p = 0.002), with overall incidences of complications of 36.8% and 23.8%, respectively. Minor pneumothorax without drainage was slightly increased in ROSE group compared with non-ROSE group (14.1% vs. 6.6%; p = 0.046). However, there was no significant difference in serious complications between the two groups.
CONCLUSION: ROSE was highly consistent with the final clinicopathological diagnosis for suspected lung cancer. ROSE further improved the diagnostic efficiency of CT-guided TCNB with no increased incidence of serious complications.
PMID:35362154 | DOI:10.1111/cyt.13123
