J Med Virol. 2022 Apr 13. doi: 10.1002/jmv.27778. Online ahead of print.
ABSTRACT
BACKGROUND: The exposure of healthcare workers (HCWs) to SARS-CoV-2 has been a major concern since the beginning of the COVID-19 pandemic. The study aimed to investigate the relationship between vaccination status and the status of catching COVID-19 in HCWs working in a Training and Research Hospital in Turkey, and the clinical course of the disease in those who were caught.
METHODS: In the current study, the vaccination status of 1279 HCWs working at Siirt Training and Research Hospital during the period when the SARS CoV-2 Delta variant was dominant, their cases of catching COVID-19 during this period, and the clinical course of the disease in patients with COVID-19 were investigated retrospectively.
RESULTS: We found that the rate of COVID-19 transmission was lowest in fully vaccinated HCWs (p<0.05). The rate of COVID-19 transmission in HCWs who received 2 doses of BioNTech vaccine (4.4%) and 2 doses of CoronaVac+1 dose of BioNTech vaccines (2.7%) was considerably lower than those without vaccination (26.2%) (p<0.05). The transmission rate was lowest among those vaccinated with 2 doses of CoronaVac+1 dose of BioNTech. Hospitalization was not required in fully vaccinated HCWs. The lymphocyte count was found to be significantly higher in fully vaccinated patients than incompletely vaccinated and unvaccinated patients. Although CRP, d-dimer, ferritin values were higher in unvaccinated and partially vaccinated patients than in fully vaccinated patients, the differences were not statistically significant.
CONCLUSION: As a result, the transmission rate of COVID-19 was lowest in fully vaccinated HCWs and in those vaccinated with 2 doses of CoronaVac+1 dose of BioNTech. In fully vaccinated HCWs, hospitalization was not needed. This article is protected by copyright. All rights reserved.
PMID:35419851 | DOI:10.1002/jmv.27778
