J Cosmet Dermatol. 2022 May 4. doi: 10.1111/jocd.15039. Online ahead of print.
ABSTRACT
BACKGROUND: Early detection of psoriasis is still an open discussion. Psoriatic lesions are characterized by red/scaly plaques affecting different body-sites.
OBJECTIVES: To evaluate the levels of Programmed cell death protein-1(PD-1) and Angiopoietins-2(Ang-2) in serum,lesional and perilesional of psoriatic patients and correlating them with controls and disease severity.
SUBJECTS AND METHODS: Serum samples were obtained from 40 participants subdivided equally into psoriatic and healthy controls, 4mm punch_biopsy equally from lesional and perilesional skin of individuals. PD-1/ANG-2 ELISA kits were used for determining the serum and tissue levels among groups.
RESULTS: Serum and tissue levels of PD-1 and Ang-2 were overexpressed in psoriatic patients compared to controls. There was a statistical difference between patients and controls in level of PD-1(serum and tissue) with p-value 0.006 and 0.0001 respectively. There was a statistical difference between both groups for ANG-2(serum and tissue) with p-value 0.03 and 0.0001 respectively. There were positive correlations between PASI score and PD-1 in tissue (r=0.467, p=0.038). Also, positive correlation between the level of PD-1 in serum and tissue (r=0.369,p=0.019), the serum levels of PD-1 and ANG-2 (r=0.78,p>0.0001), PD-1 and Ang-2 in tissue (r=0.583,p=0.0001) were detected.
CONCLUSION: PD-1 and ANG-2 can be highly recommended to determine the severity of psoriasis.
PMID:35506216 | DOI:10.1111/jocd.15039
