Retina. 2022 May 12. doi: 10.1097/IAE.0000000000003530. Online ahead of print.
ABSTRACT
PURPOSE: This study aims to assess the relationship between choroidal overall and sublayer thickness and AMD stage progression.
METHODS: A prospective, observational case series was performed. 262 eyes of 262 patients with different stages of AMD were imaged by Optical Coherence Tomography (OCT). AMD stage, choroidal thickness (CT), Sattler layer-choriocapillaris complex thickness (SLCCT) and Haller layer thickness (HLT) were determined at the baseline visit, at a 1-year follow-up visit, at a 2-year follow up visit and at a final visit (performed after a mean of 5 ± 1 years from the baseline visit).
RESULTS: Baseline AMD stages were distributed as follows: early AMD (30 eyes; 12%), intermediate AMD (97 eyes; 39%) and late AMD (126 eyes; 49%). At the final follow-up, AMD stages were so distributed: early AMD (14 eyes; 6%), intermediate AMD (83 eyes; 33%) and late AMD (156 eyes; 61%). Each group showed a statistically significant decrease in CT values over the entire follow-up (p <0.001) and SLCCT reduction was associated with AMD progression (p <0.001). Moreover, SLCCT quantitative cutoffs <20.50 µm and <10.5 µm were associated with a moderate and high probability of AMD progression, respectively, and SLCCT quantitative cutoffs <18.50 µm and <8.50 µm implied a moderate and high probability of macular neovascularization (MNV) onset, respectively.
CONCLUSIONS: Progressive choroidal impairment contributes to AMD progression. Among choroidal layers, a reduced SLCCT is a promising biomarker of disease worsening and its quantitative evaluation could help to identify patients at higher risk of stage advancement.
PMID:35594570 | DOI:10.1097/IAE.0000000000003530
