World Neurosurg. 2022 Jul 1:S1878-8750(22)00914-7. doi: 10.1016/j.wneu.2022.06.129. Online ahead of print.
ABSTRACT
OBJECTIVE: Angiographic treatment of asymptomatic cerebral vasospasm in aneurysmal subarachnoid hemorrhage remains controversial. We sought to investigate its relationship with the development of delayed cerebral ischemia.
METHODS: Consecutive patients admitted between July 2017 and June 2019, with a diagnosis of aneurysmal subarachnoid hemorrhage, were retrospectively analyzed. The rate of development of delayed cerebral ischemia was compared between a group of patients who underwent cerebral angiography for asymptomatic cerebral vasospasm and those who did not. The Mann-Whitney U test or chi-square test was used to compare the two groups.
RESULTS: 37 of the 94 patients with aneurysmal subarachnoid hemorrhage were screened for cerebral vasospasm, of whom 16 (43%) had moderate-severe vasospasm. When patients who underwent therapeutic cerebral angiography were compared with those who did not, and after adjusting for sex, age, and grade of subarachnoid hemorrhage, treatment was not found to be significantly associated with delayed cerebral ischemia (HR=0.82, 95% CI: 0.19-3.52, p=0.79). We found that the median length of stay in the intensive care unit and hospital increased significantly with the severity of cerebral vasospasm (p<0.001).
CONCLUSIONS: Cerebral angiography has a low rate of detecting moderate-severe cerebral vasospasm in asymptomatic patients. Moreover, there was no statistically significant difference in the rate of delayed cerebral ischemia between asymptomatic patients treated versus those not treated for cerebral vasospasm.There was significant association between the severity of CVS and the ICU and hospital length of stay. More studies are needed to evaluate the utility of treating asymptomatic cerebral vasospasm in high-grade aneurysmal subarachnoid hemorrhage.
PMID:35787959 | DOI:10.1016/j.wneu.2022.06.129
