J Clin Sleep Med. 2022 Aug 15. doi: 10.5664/jcsm.10228. Online ahead of print.
ABSTRACT
STUDY OBJECTIVES: To describe the outcomes of central sleep apnea (CSA) requiring home supplemental oxygen therapy in otherwise healthy term infants.
METHODS: All children <1 year of age undergoing polysomnography (PSG) between 2015-2020 at the Queensland Children’s Hospital were retrospectively studied. Children with gestational age <37 weeks, underlying syndrome, cleft palate, those with obstructive apnea-hypopnea index (OAHI) >50% of total apnea-hypopnea index (AHI) or with underlying cardiac or pulmonary parenchymal pathology were excluded. PSG parameters were extracted for periods both on and off supplemental oxygenation.
RESULTS: Fifty-two [mean (SD) age at PSG 32.6 (34.7) days; 21F] term infants were included. There was a statistically significant improvement in AHI on supplemental oxygen [Mean (SD) in room air 50.2 (36.3) vs 11.6 (9), p< 0.001 on supplemental oxygen], in both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep, as well as in mean oxygen saturations (96.6% in room air to 98.9% on oxygen; p<0.001). There was no statistically significant change in transcutaneous carbon dioxide levels or sleep duration. Oxygenation was prescribed for a median (interquartile range=IQR) age of 197 (127) days.
CONCLUSIONS: CSA in term infants who are otherwise healthy generally has a good prognosis, with oxygen therapy prescribed for around six months. Oxygen therapy was associated with improved saturations and decrease in AHI when assessed with PSG.
PMID:35962944 | DOI:10.5664/jcsm.10228
