J Periodontol. 2022 Nov 18. doi: 10.1002/JPER.22-0511. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate the clinical and radiographic significance of using a mixture of mineralized and demineralized allografts in combination (M) or not (NM) with a resorbable cross-linked barrier membrane in the reconstructive therapy of peri-implantitis defects.
METHODS: A two-arm randomized clinical trial was performed in patients diagnosed with peri-implantitis that exhibited contained defects. Clinical parameters were recorded at baseline (T<sub>0</sub> ), 6 months (T<sub>1</sub> ) and 12 months (T<sub>2</sub> ). Radiographic parameters were recorded at T<sub>0</sub> and T<sub>2</sub> . A composite criteria for disease resolution was defined a priori. A generalized linear model (GLM) of repeated measures with generalized estimation equations (GEE) statistical methods were used.
RESULTS: Overall, 33 patients (n<sub>implants</sub> = 48) completed the study. At T<sub>2</sub> , mean disease resolution was 77.1%. The use of a barrier membrane did not enhance the probability of disease resolution at T<sub>2</sub> (OR = 1.55, p = 0.737). Conversely, the odds of disease resolution were statistically associated with modified plaque index (mPI) recorded at T<sub>0</sub> (OR = 0.13, p = 0.006) and keratinized mucosa (KM) width (OR = 2.10, p = 0.035). Moreover, women exhibited greater odds to show disease resolution (OR = 5.56, p = 0.02).
CONCLUSION: Reconstructive therapy by means of a mixture of mineralized and demineralized allografts is effective in clinically resolving peri-implantitis and in gaining radiographic marginal bone level. The addition of a barrier membrane to reconstructive therapy of peri-implantitis does not seem to enhance the outcomes of contained bone defects (NCT05282667). This article is protected by copyright. All rights reserved.
PMID:36399349 | DOI:10.1002/JPER.22-0511
