Arthritis Care Res (Hoboken). 2023 Jan 30. doi: 10.1002/acr.25095. Online ahead of print.
ABSTRACT
OBJECTIVE: Population-based studies on the familial aggregation of gout are scarce and gene-environment interactions are not well-studied. We aimed to evaluate the familial aggregation of gout, as well as assess interactions between family history and obesity or alcohol consumption on the development of gout.
METHODS: Using the National Health Insurance database, which includes information on familial relationships and risk factor data, we identified 5,524,403 individuals from 2002-2018. Familial risk was calculated using hazard ratios (HRs) with 95% confidence intervals (CIs) which compare the risk of individuals with and without affected first-degree relatives (FDRs). Interactions between family history and obesity/alcohol consumption were assessed on an additive scale using the relative excess risk due to interaction (RERI).
RESULTS: Individuals with a gout-affected FDR had a 2.42-fold (95% CI 2.39-2.46) increased risk of disease compared to those with unaffected FDR. Having both a positive family history of gout and either overweight or moderate alcohol consumption was associated with a markedly increased risk of disease, with HRs of 4.39 (95% CI 4.29-4.49) and 2.28 (95% CI 2.22-2.35), respectively, which exceeded the sum of their individual risks, but was statistically significant only for overweight (RERI 0.96 95% CI 0.85-1.06). Obese individuals (RERI 1.88 95% CI 1.61-2.16) and heavy drinkers (RERI 0.36 95% CI 0.20-0.52) showed a more prominent interaction than overweight individuals and moderate drinkers, suggesting a dose-response interaction pattern.
CONCLUSION: Our findings indicate the possibility of an interaction between gout-associated genetic factors and obesity/alcohol consumption. This article is protected by copyright. All rights reserved.
PMID:36714912 | DOI:10.1002/acr.25095
