Diabet Med. 2023 Apr 8:e15108. doi: 10.1111/dme.15108. Online ahead of print.
ABSTRACT
AIMS: The contemporary prescription patterns of antidiabetic drugs following guideline changes recommending metformin as first-line gestational diabetes (GDM) pharmacotherapy is underexplored. We aimed to examined use of metformin and insulin during pregnancy among women with GDM over 20 years in the United Kingdom.
METHODS: We conducted a population-based cohort study using linked data from the Clinical Practice Research Datalink, its pregnancy register, and Hospital Episode Statistics from 1998-2017. We included pregnancies of women without prior diabetes history who received GDM diagnosis or initiated an antidiabetic drug after 20 weeks gestation. Patient-level and practice-level characteristics were compared between metformin initiators and insulin initiators. We described trends of initiating metformin as first-line treatment and described time to initiation of rescue insulin overall, and by body mass index among metformin initiators.
RESULTS: Our cohort included 5,633 pregnancies from 5,393 women with GDM, of whom 39.6% initiated pharmacotherapy (41% insulin, 59% metformin). Metformin prescriptions (as opposed to insulin) increased substantially, from < 5% of pregnancies before 2007 to 42.5%. Since 2008. Over 85% of pregnancies that were prescribed a pharmacotherapy were prescribed metformin as first-line treatment in 2015. Among metformin initiators, 16% initiated rescue insulin, typically occurring within 40 days of metformin initiation. Choice of GDM pharmacotherapy varied by characteristics, including smoking, obesity, race/ethnicity, and general practice regions.
CONCLUSIONS: Metformin was the most prescribed medication for GDM, with large increases over the past 2 decades. The increasing use of oral-antidiabetic drugs during pregnancy, consistent with other regions, highlights the need for future studies examining effectiveness and safety of antidiabetic drug use during pregnancy.
PMID:37029772 | DOI:10.1111/dme.15108
