Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Apr 28:S2451-9022(23)00102-7. doi: 10.1016/j.bpsc.2023.04.007. Online ahead of print.
ABSTRACT
OBJECTIVE: Integrating multiple neuroimaging modalities to identify clusters of individuals, and then associating these clusters with psychopathology, is a promising approach for understanding neurobiological mechanisms that underlie psychopathology and the extent to which these features are associated with clinical symptoms.
METHOD: We leveraged neuroimaging data from T1-weighted, diffusion-weighted, and resting-state functional magnetic resonance images from the Adolescent Brain and Cognitive Development Study (N=8035) and used Similarity Network Fusion and spectral clustering to identify subgroups of participants. We examined neuroimaging measures as a function of clustering profiles using one, two, or three imaging modalities (i.e., data combinations), calculated the stability of the clustering assignment in each respective data combination, and compared the consistency of clusters across different data combinations. We then compared the extent to which clusters were associated with overall psychopathology, at the baseline assessment, and two-yearly follow-up visits.
RESULTS: Each data combination resulted in optimal clusters, ranging from two to four subgroups for each data combination. Clusters were stable across sub-sampling of the ABCD cohort. Widespread structural measures (surface area, fractional anisotropy, and mean diffusivity) were important features contributing to clustering across different data combinations. Five of the seven data combinations were associated with overall psychopathology, at baseline and over time (d=0.08-0.41). Generally, lower global cortical volume and surface area, widespread reduced fractional anisotropy, and increased radial diffusivity were associated with increased overall psychopathology.
CONCLUSION: Profiles constructed from neuroimaging data combinations are associated with concurrent and future psychopathology trajectories.
PMID:37121399 | DOI:10.1016/j.bpsc.2023.04.007
