J Clin Endocrinol Metab. 2023 Aug 17:dgad473. doi: 10.1210/clinem/dgad473. Online ahead of print.
ABSTRACT
BACKGROUND: Large extracellular vesicles (lEV) enriched for endothelial and blood cell markers are increased in metabolic conditions such as obesity or type 2 diabetes (T2D), actively contribute to the atherosclerosis process, and have been identified as diagnostic and prognostic biomarkers for cardiovascular disease (CVD). Although bariatric surgery (BS) in individuals with obesity is related to decreased cardiovascular (CV) risk and increased life expectancy, post-BS these subjects are still at higher CV risk compared to the general population. We aimed to compare the lEV profiles between individuals with obesity, with or without T2D, before and 1-year after BS, and normal-weight controls.
METHODS: Prospective longitudinal study with individuals eligible for BS, with or without T2D (T2D and OB groups, respectively) and healthy controls (HC-group) matched by age and sex. The concentration and phenotype of lEV were assessed by flow cytometry.
RESULTS: The study cohort included 108 individuals (age 48.0 ± 10.5 years; 84.3% females). Before BS, the OB-group presented higher concentrations of lEV enriched for endothelial and blood cell biomarkers than the HC, but lower concentrations than those observed in the T2D-group (p < 0.05). BS resulted in a significant reduction in most of the lEV enriched for cell-specific markers in both subgroups. lEV differences between OB and T2D groups were no longer observed post-BS (p > 0.05). However, compared with HC, OB and T2D groups still showed increased concentrations of lEV enriched for platelet and endothelial cell markers (p < 0.05).
CONCLUSION: At one year after BS, lEV concentrations remain above the physiological range. These abnormalities might contribute to explaining the increased CV risk after BS and underscore the importance of long-term CV risk factor control in post-BS individuals.
PMID:37589958 | DOI:10.1210/clinem/dgad473
