Complement Ther Med. 2023 Aug 22:102974. doi: 10.1016/j.ctim.2023.102974. Online ahead of print.
ABSTRACT
BACKGROUND: Royal jelly (RJ) may contribute to glycemic control and liver function through various mechanisms. The present study aimed to quantify the effect of RJ supplementation on these outcomes.
METHODS: A literature search of Web of Science, Scopus, and PubMed/Medline, was conducted for RCTs investigating the efficacy of RJ on plasma liver enzymes and glycemic indices. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated for net changes using a random-effects model.
RESULTS: Ten RCTs were selected for inclusion in this meta-analysis. Combined estimate of effect sizes for the impact of RJ on neither the plasma liver enzymes nor the glycemic indices were statistically significant. Subgroup analysis showed a significant reduction of serum FPG in trials with intervention duration ≥8 weeks (WMD: -4.28mg/dl, 95% CI -7.41 to -1.14mg/dl, p =0.007), and those conducted in non-healthy populations (WMD: -4.28mg/dl, 95% CI -7.41 to -1.14, p = 0.007).
CONCLUSION: RJ does not significantly affect liver function and glycemic profile of adult population. In trials with longer intervention and those conducted in non-healthy populations a significant reduction of serum FBG was observed. This meta-analysis should be repeated in the future, with more primary articles included, in order to provide conclusive results.
PMID:37619715 | DOI:10.1016/j.ctim.2023.102974
