J Pediatr. 2023 Aug 26:113700. doi: 10.1016/j.jpeds.2023.113700. Online ahead of print.
ABSTRACT
OBJECTIVE: To determine the ability of the Bayley-III cognitive and language composite scores at 18-22 months corrected age to predict WISC-IV Full Scale IQ (FSIQ) at 6-7 years in infants born extremely preterm.
STUDY DESIGN: Children in this study were part of the Neuroimaging and Neurodevelopmental Outcome (NEURO) cohort, a secondary study to the SUPPORT trial and born 24 to 27.6 weeks gestational age. Bayley-III cognitive and language scores and WISC-IV FSIQ were compared with pairwise Pearson correlation coefficients and adjusted for medical and socio-economic variables using linear mixed effect regression models.
RESULTS: Bayley-III cognitive (r=0.33) and language scores (r=0.44) were mildly correlated with WISC-IV FSIQ score. Of the children with Bayley-III cognitive scores less than 70, 67% also had FSIQ <70. There was less consistency for children with Bayley-III scores in the 85-100 range as 43% had FSIQ <85 and 10% FSIQ <70. Among those with Bayley-III language scores >100, about 1 in 5 had FSIQ <85. A cut point of 92 for the cognitive composite score resulted in sensitivity (0.60), specificity (0.64). A cut point of 88 for the language composite score produced sensitivity (0.61), specificity (0.70).
CONCLUSION: Findings indicate the Bayley-III cognitive and language scores correlate with later IQ but may fail to predict delay or misclassify children who are not delayed at school age. The Bayley-III can be a useful tool to help identify children born extremely preterm who have below average cognitive scores and may be at the greatest risk for ongoing cognitive difficulties.
PMID:37640232 | DOI:10.1016/j.jpeds.2023.113700
