J Occup Environ Med. 2023 Sep 19. doi: 10.1097/JOM.0000000000002973. Online ahead of print.
ABSTRACT
OBJECTIVE: We aimed to evaluate the enzyme activity of chitotriosidase as a biomarker in early diagnosis silicosis, and to investigate immune system response and oxidative stress caused by silica exposure.
MATERIALS AND METHODS: Silicosis patients (n = 116), exposed to silica without disease (n = 76), and healthy individuals(n = 55) were included. Serum levels of chitotriosidase, proinflammatory cytokines, oxidant-antioxidant and immune parameters were measured.
RESULTS: Serum chitotriosidase enzyme levels in the silicosis group were statistically significantly higher than the exposure and control groups. Inflammatory biomarkers, 8-hydroxy-2-deoxyguanosine levels were found to be statistically significantly higher in the silicosis and exposure group compared to the controls, while superoxide dismutase and glutathione peroxidase were lower.
CONCLUSION: Increased serum chitotriosidase level emerged as a biomarker that can not only distinguish silicosis from exposure and healthy controls, but also indicate early pulmonary effects of silica.
PMID:37733997 | DOI:10.1097/JOM.0000000000002973
