Clin Lab. 2024 Nov 1;70(11). doi: 10.7754/Clin.Lab.2024.240608.
ABSTRACT
BACKGROUND: This study aimed to investigate the effect and clinical implications of IL-1β on the development of aneurysmal subarachnoid hemorrhage.
METHODS: This retrospective study included a total of 80 participants, and these participants were divided into the following two groups: control group (healthy participants) and experimental group (aneurysmal subarachnoid hemorrhage patients). Then, all of the participants received digital subtraction angiography or computed tomography angiography. Participants’ general data were collected and analyzed. IL-1β expression in blood samples were determined by ELISA, and then IL-1β protein were determined by western blotting.
RESULTS: A total of 80 participants was included in this study, and the participants` general data, including gender, age, and previous medical history, showed no significant differences between the experimental group and control group. The IL-1β value in the experimental group was significantly increased, and the difference was statistically significant (p < 0.05).
CONCLUSIONS: Upregulated IL-1β can promote the development of aneurysmal subarachnoid hemorrhage, indicating that IL-1β is a key factor in evaluating the prognosis of patients with aneurysmal subarachnoid hemorrhage.
PMID:39506594 | DOI:10.7754/Clin.Lab.2024.240608
