Methods Mol Biol. 2025;2871:179-191. doi: 10.1007/978-1-0716-4217-7_17.
ABSTRACT
The planarian Schmidtea mediterranea shows nutrient-dependent whole-body plasticity. Starvation leads to body size reduction, while feeding triggers growth. The balance of cell proliferation and cell death controls cell number, driving organismal body size. Here, we uncovered the role of FoxO in controlling cell death through TUNEL and caspase-3 assays and bak qPCR detection in foxO RNAi planarians.
PMID:39565589 | DOI:10.1007/978-1-0716-4217-7_17
