Indian J Dent Res. 2025 Feb 28. doi: 10.4103/ijdr.ijdr_271_24. Online ahead of print.
ABSTRACT
BACKGROUND: Periodontal diseases necessitate adjunctive therapies alongside mechanical debridement. Spirulina platensis, recognized for its antimicrobial properties and minimal side effects, offers promise in periodontal treatment.
AIMS: This study compares the efficacy of subgingivally delivered spirulina gel with chlorhexidine (CHX) gel both clinically and microbiologically in stage III periodontitis patients.
METHODS AND MATERIALS: A randomized, controlled, single-blinded, split-mouth study was conducted with 23 subjects meeting inclusion and exclusion criteria. The participants were randomly assigned to two treatment groups: Group I (control) received scaling and root planing (SRP) followed by 1% CHX gel, and Group II (test) received SRP followed by 4% spirulina gel. Clinical parameters such as Gingival Index (GI), Modified Sulcular Bleeding Index (mSBI), and probing depth were assessed at baseline, 3rd week, and 6th week. Microbial load assessment for Porphyromonas gingivalis (P.g) was conducted using real-time qPCR at baseline and 6th week.
STATISTICAL ANALYSIS USED: Paired t-tests, repeated measures analyses of variance using SPSS software.
RESULTS: Both groups exhibited significant improvements in clinical parameters and reduced P.g load, with no significant difference between the spirulina and CHX groups.
CONCLUSION: The findings suggest that 4% spirulina gel, when delivered subgingivally can be considered a viable adjunct to non-surgical periodontal therapy, offering a natural and potentially cost-effective alternative to traditional antimicrobial agents.
PMID:40016818 | DOI:10.4103/ijdr.ijdr_271_24
