Sci Rep. 2025 Apr 5;15(1):11694. doi: 10.1038/s41598-025-96069-5.
ABSTRACT
Health-related social needs (HRSN) significantly influence healthcare utilization and outcomes. While prior studies have shown higher rates of hospital readmissions among individuals with HRSN, the impact of HRSN on hospital readmissions in persons living with HIV (PLWH) at population level, using ICD10 codes for HRSN in hospital discharge data, has not been fully explored. In this retrospective study using the 2016-2019 Florida and Maryland State Inpatient Database (SID), we examined the prevalence of HRSN among hospitalized PLWH using ICD-10 diagnosis codes including the domains of employment, family, housing, psychosocial, and education. In addition to descriptive analysis, we used multivariable logistic regression models to evaluate the association between hospital readmission and the presence of HRSN, controlling for potential confounders. In Florida, we identified 43,229 PLWH patients, of whom 9.6% (4,153) had HRSN. PLWH with HRSN had a significantly higher 90-day (40.6% vs. 23.1%) and one-year (73.6% vs. 41.3%) readmission rates compared with those without HRSN. Multivariable regression analysis showed that patients with HRSN had nearly three times the odds of 90-day readmission [adjusted odds ratio (aOR): 2.80 (95% confidence interval (CI): 2.61-3.01)] and four times the odds of one-year readmission [aOR: 3.93(95% CI: 3.62-4.27)]. In the Maryland SID, 12.5% (1,551) of the 12,396 PLWH had HRSN. PLWH with documented HRSN had a significantly higher 90-day (39.9% vs. 20.4%) and one-year (68.2% vs. 37.9%) readmission rates than those without HRSN. In multivariable regression analysis, HRSN were similarly associated with substantially higher odds of 90-day readmission [aOR: 2.70(95% CI: 2.38-3.05)] and one-year readmission [aOR: 3.60(95% CI: 3.15-4.12)]. In both states, there was a dose-response relationship between the number of HRSN and readmission rates. In conclusion, the prevalence of HRSN is associated with significantly higher rates of hospital readmissions among PLWH. Our findings highlight the importance of accounting for social factors when studying hospital readmissions and call for the development of interventions targeting HRSN to reduce readmissions in PLWH.
PMID:40188258 | DOI:10.1038/s41598-025-96069-5
