Sci Rep. 2025 Apr 10;15(1):12221. doi: 10.1038/s41598-025-97578-z.
ABSTRACT
Patients with diabetes had significant vascular resistance, which was explained by vascular remodeling and an increase in fluid volume as a result of hyperglycemia. Insulin resistance in type 2 diabetes impairs lipid catabolism, and obesity raises the risk of isolated systolic hypertension. However, in Ethiopia minimal study has been conducted to address the specific relationship between isolated systolic hypertension and type 2 diabetes. Therefore, this study aims to determine the magnitude and determinants of isolated systolic hypertension among type 2 diabetes patients in selected referral hospitals of Amhara region, Ethiopia. A multicenter institution-based cross-sectional study was conducted from September 1 and December 30, 2023. Referral hospitals were chosen using simple random sampling. Additionally, participants in the study were chosen from the designated referral hospitals using systematic sampling approaches. To collect clinical and sociodemographic data, an interviewer-administered questionnaire was utilized. Epi-data version-4.6 and Stata-14 were used for data entry and statistical analysis, respectively. The descriptive statistics were presented with tables and graphs. A binary logistic regression model was fitted to identify associated factors of isolated systolic hypertension. In the final model, statistical significance was decided at p ≤ 0.05, and the strength of association was indicated using an adjusted odds ratio with 95% CI. The analysis included 258 participants, and the prevalence of isolated systolic hypertension was found to be 21.3% (95% CI 18-27.1%). Older age (AOR = 4.64, 95%CI 1.31,16.36), fasting blood sugar of ≥ 130 mg/dl (AOR = 2.32, 95% CI; 1.04, 5.19), and BMI > 25 Kg/m2 (AOR = 2.75, 95% CI (1.33, 5.68)) were statistically significant factors of isolated systolic hypertension. The prevalence of isolated systolic hypertension (ISH) in this study was high, affecting large population of Type 2 Diabetes Mellitus (T2DM) patients. Older age, high body mass index (BMI), and elevated fasting blood sugar levels were identified as key determinants of ISH. The study emphasizes the need for regular monitoring and management of blood pressure in T2DM patients, particularly those who are older, and have higher BMI.
PMID:40211033 | DOI:10.1038/s41598-025-97578-z
